Randomized phase II trial of sipuleucel-T with or without radium-223 in men with bone-metastatic castration-resistant prostate cancer

PURPOSE: To investigate if radium-223 increases peripheral immune responses to sipuleucel-T in men with bone-predominant, minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). METHODS: 32 patients were randomized 1:1 in this open label, phase 2 multicenter trial. Patients in...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Marshall, Catherine H., Fu, Wei, Wang, Hao, Park, Jong Chul, DeWeese, Theodore L., Tran, Phuoc T., Song, Daniel Y., King, Serina, Afful, Michaella, Hurrelbrink, Julia, Manogue, Charlotte, Cotogno, Patrick, Moldawer, Nancy P., Barata, Pedro C., Drake, Charles G., Posadas, Edwin M., Armstrong, Andrew J., Sartor, Oliver, Antonarakis, Emmanuel S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121020/
https://ncbi.nlm.nih.gov/pubmed/33451978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4476
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