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A New Highly Deuterated [(18)F]AV-45, [(18)F]D15FSP, for Imaging β-Amyloid Plaques in the Brain
[Image: see text] [(18)F]AV-45 (florbetapir f18, Amyvid) is an FDA-approved PET imaging agent targeting Aβ plaques in the brain for diagnosis of Alzheimer’s disease (AD). Its metabolites led to a high background in the brain and large bone uptake of [(18)F]F(–), produced from dealkylation of the PEG...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2021
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8274066/ https://ncbi.nlm.nih.gov/pubmed/34267878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00062 |
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