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A New Highly Deuterated [(18)F]AV-45, [(18)F]D15FSP, for Imaging β-Amyloid Plaques in the Brain

[Image: see text] [(18)F]AV-45 (florbetapir f18, Amyvid) is an FDA-approved PET imaging agent targeting Aβ plaques in the brain for diagnosis of Alzheimer’s disease (AD). Its metabolites led to a high background in the brain and large bone uptake of [(18)F]F(–), produced from dealkylation of the PEG...

詳細記述

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Xiao, Hao, Choi, Seok Rye, Zhao, Ruiyue, Ploessl, Karl, Alexoff, David, Zhu, Lin, Zha, Zhihao, Kung, Hank F.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2021
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274066/
https://ncbi.nlm.nih.gov/pubmed/34267878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00062
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