Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt

[Image: see text] The inhibition of the nuclear receptor retinoic-acid-receptor-related orphan receptor γt (RORγt) is a promising strategy in the treatment of autoimmune diseases. RORγt features an allosteric binding site within its ligand-binding domain that provides an opportunity to overcome draw...

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Publicado en:J Med Chem
Main Authors: Meijer, Femke A., Saris, Annet O.W.M., Doveston, Richard G., Oerlemans, Guido J.M., de Vries, Rens M.J.M., Somsen, Bente A., Unger, Anke, Klebl, Bert, Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2021
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273893/
https://ncbi.nlm.nih.gov/pubmed/34008974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00475
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