Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells

Intestinal epithelial stem cells are highly sensitive to differentiation induced by endoplasmic reticulum (ER) stress. Colorectal cancer develops from mutated intestinal epithelial stem cells. The most frequent initiating mutation occurs in Apc, which results in hyperactivated Wnt signalling. This c...

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Pubblicato in:Oncogene
Autori principali: van Lidth de Jeude, JF, Meijer, BJ, Wielenga, MCB, Spaan, CN, Baan, B, Rosekrans, SL, Meisner, S, Shen, YH, Lee, AS, Paton, JC, Paton, AW, Muncan, V, van den Brink, GR, Heijmans, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272398/
https://ncbi.nlm.nih.gov/pubmed/27819675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.326
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