Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation

Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Her...

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Publicado no:Cancer Res
Main Authors: van Lidth de Jeude, Jooske F., Spaan, Claudia N., Meijer, Bartolomeus J., Smit, Wouter L., Soeratram, Tanya T.D., Wielenga, Mattheus C.B., Westendorp, B. Florien, Lee, Amy S., Meisner, Sander, Vermeulen, Jacqueline L.M., Wildenberg, Manon E., van den Brink, Gijs R., Muncan, Vanesa, Heijmans, Jarom
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272399/
https://ncbi.nlm.nih.gov/pubmed/30232220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3600
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