Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation

Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Her...

詳細記述

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書誌詳細
出版年:Cancer Res
主要な著者: van Lidth de Jeude, Jooske F., Spaan, Claudia N., Meijer, Bartolomeus J., Smit, Wouter L., Soeratram, Tanya T.D., Wielenga, Mattheus C.B., Westendorp, B. Florien, Lee, Amy S., Meisner, Sander, Vermeulen, Jacqueline L.M., Wildenberg, Manon E., van den Brink, Gijs R., Muncan, Vanesa, Heijmans, Jarom
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272399/
https://ncbi.nlm.nih.gov/pubmed/30232220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3600
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