Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation

Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Her...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cancer Res
Glavni autori: van Lidth de Jeude, Jooske F., Spaan, Claudia N., Meijer, Bartolomeus J., Smit, Wouter L., Soeratram, Tanya T.D., Wielenga, Mattheus C.B., Westendorp, B. Florien, Lee, Amy S., Meisner, Sander, Vermeulen, Jacqueline L.M., Wildenberg, Manon E., van den Brink, Gijs R., Muncan, Vanesa, Heijmans, Jarom
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272399/
https://ncbi.nlm.nih.gov/pubmed/30232220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3600
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items