Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice

Brain endothelial cells (BECs) are involved in the pathogenesis of ischemic stroke. Recently, several microRNAs (miRNAs) in BECs were reported to regulate the endothelial function in ischemic brain. Therefore, modulation of miRNAs in BECs by a therapeutic oligonucleotide to inhibit miRNA (antimiR) c...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Suzuki, Motohiro, Ishibashi, Satoru, Iwasawa, Eri, Oguma, Takahiro, Saito, Yasuhiro, Li, Fuying, Otsu, Shinichi, Ichinose, Keiko, Yoshioka, Kotaro, Nagata, Tetsuya, Yokota, Takanori
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270953/
https://ncbi.nlm.nih.gov/pubmed/34244578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93666-y
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