Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice

Brain endothelial cells (BECs) are involved in the pathogenesis of ischemic stroke. Recently, several microRNAs (miRNAs) in BECs were reported to regulate the endothelial function in ischemic brain. Therefore, modulation of miRNAs in BECs by a therapeutic oligonucleotide to inhibit miRNA (antimiR) c...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Suzuki, Motohiro, Ishibashi, Satoru, Iwasawa, Eri, Oguma, Takahiro, Saito, Yasuhiro, Li, Fuying, Otsu, Shinichi, Ichinose, Keiko, Yoshioka, Kotaro, Nagata, Tetsuya, Yokota, Takanori
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270953/
https://ncbi.nlm.nih.gov/pubmed/34244578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93666-y
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