Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice

Brain endothelial cells (BECs) are involved in the pathogenesis of ischemic stroke. Recently, several microRNAs (miRNAs) in BECs were reported to regulate the endothelial function in ischemic brain. Therefore, modulation of miRNAs in BECs by a therapeutic oligonucleotide to inhibit miRNA (antimiR) c...

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Udgivet i:Sci Rep
Main Authors: Suzuki, Motohiro, Ishibashi, Satoru, Iwasawa, Eri, Oguma, Takahiro, Saito, Yasuhiro, Li, Fuying, Otsu, Shinichi, Ichinose, Keiko, Yoshioka, Kotaro, Nagata, Tetsuya, Yokota, Takanori
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270953/
https://ncbi.nlm.nih.gov/pubmed/34244578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93666-y
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