In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model

Background: Elimination of a drug during renal replacement therapy is not only dependent on flow rates, molecular size and protein binding, but is often influenced by difficult to predict drug membrane interactions. In vitro models allow for extensive profiling of drug clearance using a wide array o...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Vossen, M G, Pferschy, S, Milacek, C, Haidinger, M, Karolyi, Mario, Vass, Zoltan, Burgmann, Heinz, Maier-Salamon, Alexandra, Wicha, S G, Jäger, W, Zeitlinger, M, Stimpfl, T, Wittek, T, Thalhammer, F
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264131/
https://ncbi.nlm.nih.gov/pubmed/34248646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.702455
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