Pharmacokinetics of doripenem in plasma and epithelial lining fluid (ELF): comparison of two dosage regimens

PURPOSE: In 2014, FDA released a warning for prescription of doripenem for ventilator-associated bacterial pneumonia due to unsatisfactory clinical cure rates. The present study explores if the observed lack of efficacy might be explained by insufficient target site pharmacokinetics in intensive car...

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Udgivet i:Eur J Clin Pharmacol
Main Authors: Oesterreicher, Zoe, Minichmayr, Iris, Sauermann, Robert, Marhofer, Daniela, Lackner, Edith, Jäger, Walter, Maier-Salamon, Alexandra, Schwameis, Richard, Kloft, Charlotte, Zeitlinger, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2017
Fag:
Pharmacokinetics and Disposition
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684299/
https://ncbi.nlm.nih.gov/pubmed/28920154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-017-2327-y
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