TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis

Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases known as telomeropathies. Telomerase is recruited to chromosome ends by the ACD/TPP1 protein (TPP1 hereafter), a component of the shelterin c...

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Udgivet i:JCI Insight
Main Authors: Grill, Sherilyn, Padmanaban, Shilpa, Friedman, Ann, Perkey, Eric, Allen, Frederick, Tesmer, Valerie M., Chase, Jennifer, Khoriaty, Rami, Keegan, Catherine E., Maillard, Ivan, Nandakumar, Jayakrishnan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262337/
https://ncbi.nlm.nih.gov/pubmed/33822766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138059
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