Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells

Telomerase replicates chromosome ends in germ and somatic stem cells to facilitate their continued proliferation. Telomerase action depends on the telomeric protein TPP1, which recruits telomerase to telomeres and facilitates processive DNA synthesis. Here, we identify separation-of-function long (T...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Grill, Sherilyn, Bisht, Kamlesh, Tesmer, Valerie M., Shami, Adrienne Niederriter, Hammoud, Saher S., Nandakumar, Jayakrishnan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599638/
https://ncbi.nlm.nih.gov/pubmed/31216472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.073
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