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TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis
Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases known as telomeropathies. Telomerase is recruited to chromosome ends by the ACD/TPP1 protein (TPP1 hereafter), a component of the shelterin c...
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| 出版年: | JCI Insight |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8262337/ https://ncbi.nlm.nih.gov/pubmed/33822766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138059 |
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