Direct mapping of higher-order RNA interactions by SHAPE-JuMP

Higher-order structure governs function for many RNAs. However, discerning this structure for large RNA molecules in solution is an unresolved challenge. Here, we present SHAPE-JuMP (selective 2’-hydroxyl acylation analyzed by primer extension and juxtaposed merged pairs) to interrogate through-spac...

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Publié dans:Biochemistry
Auteurs principaux: Christy, Thomas W., Giannetti, Catherine A., Houlihan, Gillian, Smola, Matthew J., Rice, Greggory M., Wang, Jian, Dokholyan, Nikolay V., Laederach, Alain, Holliger, Philipp, Weeks, Kevin M.
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256721/
https://ncbi.nlm.nih.gov/pubmed/34121404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00270
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