Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic

Costimulation via CD137 (4-1BB) enhances antitumor immunity mediated by cytotoxic T lymphocytes. Anti-CD137 agonist antibodies elicit mild liver inflammation in mice, and the maximum tolerated dose of Urelumab, an anti-human CD137 agonist monoclonal antibody, in the clinic was defined by liver infla...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Etxeberria, Iñaki, Bolaños, Elixabet, Teijeira, Alvaro, Garasa, Saray, Yanguas, Alba, Azpilikueta, Arantza, Kavanaugh, William M., Vasiljeva, Olga, Belvin, Marcia, Howng, Bruce, Irving, Bryan, Tipton, Kimberly, West, James, Mei, Li, Korman, Alan J., Sega, Emanuela, Olivera, Irene, Cirella, Assunta, Ochoa, Maria C., Rodriguez, Maria E., Melero, Ana, Sanmamed, Miguel F., Engelhardt, John J., Melero, Ignacio
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255787/
https://ncbi.nlm.nih.gov/pubmed/34172583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025930118
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