Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4–1BB)

TRAF2 dependent K63-polyubiquitinations have been recently shown to connect CD137 (4–1BB) stimulation to NF-κB activation. In a search of deubiquitinase enzymes (DUBs) that could regulate such a signaling route, A20 and CYLD were found to coimmunoprecipitate with CD137 and TRAF2 complexes. Indeed, o...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Azpilikueta, Arantza, Bolaños, Elixabet, Lang, Valerie, Labiano, Sara, Aznar, Maria A., Etxeberria, Iñaki, Teijeira, Alvaro, Rodriguez-Ruiz, Maria E., Perez-Gracia, Jose L., Jure-Kunkel, Maria, Zapata, Juan M., Rodriguez, Manuel S., Melero, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739564/
https://ncbi.nlm.nih.gov/pubmed/29296520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1368605
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