Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic

Costimulation via CD137 (4-1BB) enhances antitumor immunity mediated by cytotoxic T lymphocytes. Anti-CD137 agonist antibodies elicit mild liver inflammation in mice, and the maximum tolerated dose of Urelumab, an anti-human CD137 agonist monoclonal antibody, in the clinic was defined by liver infla...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Etxeberria, Iñaki, Bolaños, Elixabet, Teijeira, Alvaro, Garasa, Saray, Yanguas, Alba, Azpilikueta, Arantza, Kavanaugh, William M., Vasiljeva, Olga, Belvin, Marcia, Howng, Bruce, Irving, Bryan, Tipton, Kimberly, West, James, Mei, Li, Korman, Alan J., Sega, Emanuela, Olivera, Irene, Cirella, Assunta, Ochoa, Maria C., Rodriguez, Maria E., Melero, Ana, Sanmamed, Miguel F., Engelhardt, John J., Melero, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255787/
https://ncbi.nlm.nih.gov/pubmed/34172583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025930118
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados