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Structurally Based Design of Glucagon Mutants that Inhibit Fibril Formation
The peptide hormone glucagon is prescribed as a pharmaceutical compound to treat diabetic hypoglycemia. However, at the acidic pH where it is highly soluble, glucagon rapidly aggregates into inactive and cytotoxic amyloid fibrils. The recently determined high-resolution structure of these fibrils re...
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| Published in: | Biochemistry |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8254510/ https://ncbi.nlm.nih.gov/pubmed/34124902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00214 |
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