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Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrilized Three-Repeat Tau Protein Revealed by Solid-State NMR Spectroscopy

Many neurodegenerative diseases such as Alzheimer’s disease are characterized by pathological β-sheet filaments of the tau protein, which spread in a prion-like manner in patient brains. To date, high-resolution structures of tau filaments obtained from patient brains show that the β-sheet core only...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Dregni, Aurelio J., Wang, Harrison K., Wu, Haifan, Duan, Pu, Jin, Jia, DeGrado, William F., Hong, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283780/
https://ncbi.nlm.nih.gov/pubmed/33983722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c03314
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