Llwytho...
Structurally Based Design of Glucagon Mutants that Inhibit Fibril Formation
The peptide hormone glucagon is prescribed as a pharmaceutical compound to treat diabetic hypoglycemia. However, at the acidic pH where it is highly soluble, glucagon rapidly aggregates into inactive and cytotoxic amyloid fibrils. The recently determined high-resolution structure of these fibrils re...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Biochemistry |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2021
|
| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8254510/ https://ncbi.nlm.nih.gov/pubmed/34124902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00214 |
| Tagiau: |
Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|