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The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations

Glucagon and insulin maintain blood glucose homeostasis and are used to treat hypoglycemia and hyperglycemia in diabetic patients, respectively. Whereas insulin is stable for weeks in its solution formulation, glucagon fibrillizes rapidly at the acidic pH required for solubility, and is therefore fo...

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Podrobná bibliografie
Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Gelenter, Martin D., Smith, Katelyn J., Liao, Shu-Yu, Mandala, Venkata S., Dregni, Aurelio J., Lamm, Matthew S., Tian, Yu, Xu, Wei, Pochan, Darrin J., Tucker, Thomas J., Su, Yongchao, Hong, Mei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609468/
https://ncbi.nlm.nih.gov/pubmed/31235909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0238-6
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