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The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations

Glucagon and insulin maintain blood glucose homeostasis and are used to treat hypoglycemia and hyperglycemia in diabetic patients, respectively. Whereas insulin is stable for weeks in its solution formulation, glucagon fibrillizes rapidly at the acidic pH required for solubility, and is therefore fo...

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書目詳細資料
發表在:Nat Struct Mol Biol
Main Authors: Gelenter, Martin D., Smith, Katelyn J., Liao, Shu-Yu, Mandala, Venkata S., Dregni, Aurelio J., Lamm, Matthew S., Tian, Yu, Xu, Wei, Pochan, Darrin J., Tucker, Thomas J., Su, Yongchao, Hong, Mei
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609468/
https://ncbi.nlm.nih.gov/pubmed/31235909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0238-6
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