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The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations

Glucagon and insulin maintain blood glucose homeostasis and are used to treat hypoglycemia and hyperglycemia in diabetic patients, respectively. Whereas insulin is stable for weeks in its solution formulation, glucagon fibrillizes rapidly at the acidic pH required for solubility, and is therefore fo...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Gelenter, Martin D., Smith, Katelyn J., Liao, Shu-Yu, Mandala, Venkata S., Dregni, Aurelio J., Lamm, Matthew S., Tian, Yu, Xu, Wei, Pochan, Darrin J., Tucker, Thomas J., Su, Yongchao, Hong, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609468/
https://ncbi.nlm.nih.gov/pubmed/31235909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0238-6
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