ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA

BACKGROUND: Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether cells distinguish aberrant from canonical methylations. METHODS: Here we use quan...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Wollen, Kristian Lied, Hagen, Lars, Vågbø, Cathrine B., Rabe, Renana, Iveland, Tobias S., Aas, Per Arne, Sharma, Animesh, Sporsheim, Bjørnar, Erlandsen, Hilde O., Palibrk, Vuk, Bjørås, Magnar, Fonseca, Davi M., Mosammaparast, Nima, Slupphaug, Geir
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254245/
https://ncbi.nlm.nih.gov/pubmed/34217309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02948-6
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