DNA unwinding by ASCC3 helicase is coupled to ALKBH3 dependent DNA alkylation repair and cancer cell proliferation

Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little is known about their functions in mammalian cells. We report the purification of the ALKBH3 complex and demonstrate its association with the Activating Signal Co-integrator...

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Detalhes bibliográficos
Main Authors: Dango, Sebastian, Mosammaparast, Nima, Sowa, Mathew E., Xiong, Li-Jun, Wu, Feizhen, Park, Keyjung, Rubin, Mark, Gygi, Steve, Harper, J. Wade, Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258846/
https://ncbi.nlm.nih.gov/pubmed/22055184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.039
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