Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease

Maturity‐onset diabetes of the young type 5 (MODY5) is due to heterozygous mutations or deletion of HNF1B. No mouse models are currently available to recapitulate the human MODY5 disease. Here, we investigate the pancreatic phenotype of a unique MODY5 mouse model generated by heterozygous insertion...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Quilichini, Evans, Fabre, Mélanie, Nord, Christoffer, Dirami, Thassadite, Le Marec, Axelle, Cereghini, Silvia, Pasek, Raymond C, Gannon, Maureen, Ahlgren, Ulf, Haumaitre, Cécile
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2021
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251562/
https://ncbi.nlm.nih.gov/pubmed/33527355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5629
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