Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis

BACKGROUND & AIMS: The exocrine pancreas consists of acinar cells that produce digestive enzymes transported to the intestine through a branched ductal epithelium. Chronic pancreatitis is characterized by progressive inflammation, fibrosis, and loss of acinar tissue. These changes of the exocrin...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Quilichini, Evans, Fabre, Mélanie, Dirami, Thassadite, Stedman, Aline, De Vas, Matias, Ozguc, Ozge, Pasek, Raymond C., Cereghini, Silvia, Morillon, Lucie, Guerra, Carmen, Couvelard, Anne, Gannon, Maureen, Haumaitre, Cécile
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722301/
https://ncbi.nlm.nih.gov/pubmed/31229598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.06.005
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