Cryo-EM Structure of Human Cannabinoid Receptor CB2-Gi Signaling Complex

Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here, we report the cryo-E...

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Publicado en:Cell
Autores principales: Xing, Changrui, Zhuang, Youwen, Xu, Ting-Hai, Feng, Zhiwei, Zhou, X. Edward, Chen, Maozi, Wang, Lei, Meng, Xing, Xue, Ying, Wang, Junmei, Liu, Heng, McGuire, Terence Francis, Zhao, Gongpu, Melcher, Karsten, Zhang, Cheng, Xu, H. Eric, Xie, Xiang-Qun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247115/
https://ncbi.nlm.nih.gov/pubmed/32004460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.01.007
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