CB2 Cannabinoid Receptor Targets Mitogenic Gi Protein–Cyclin D1 Axis in Osteoblasts

CB2 is a Gi protein–coupled receptor activated by endo- and phytocannabinoids, thus inhibiting stimulated adenylyl cyclase activity. CB2 is expressed in bone cells and Cb2 null mice show a marked age-related bone loss. CB2-specific agonists both attenuate and rescue ovariectomy-induced bone loss. Ac...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ofek, Orr, Attar-Namdar, Malka, Kram, Vardit, Dvir-Ginzberg, Mona, Mechoulam, Raphael, Zimmer, Andreas, Frenkel, Baruch, Shohami, Esther, Bab, Itai
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179350/
https://ncbi.nlm.nih.gov/pubmed/20803555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.228
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados