CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

Activation of the CB2 receptor is apparently an endogenous protective mechanism. Thus, it restrains inflammation and protects the skeleton against age-related bone loss. However, the endogenous cannabinoids, as well as Δ(9)-tetrahydrocannabinol, the main plant psychoactive constituent, activate both...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Smoum, Reem, Baraghithy, Saja, Chourasia, Mukesh, Breuer, Aviva, Mussai, Naama, Attar-Namdar, Malka, Kogan, Natalya M., Raphael, Bitya, Bolognini, Daniele, Cascio, Maria G., Marini, Pietro, Pertwee, Roger G., Shurki, Avital, Mechoulam, Raphael, Bab, Itai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507227/
https://ncbi.nlm.nih.gov/pubmed/26124120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503395112
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