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HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity

Oleoyl serine (OS), an endogenous fatty acyl amide (FAA) found in bone, has been shown to have an anti-osteoporotic effect. OS, being an amide, can be hydrolyzed in the body by amidases. Hindering its amide bond by introducing adjacent substituents has been demonstrated as a successful method for pr...

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Vydáno v:Molecules
Hlavní autoři: Baraghithy, Saja, Smoum, Reem, Attar-Namdar, Malka, Mechoulam, Raphael, Bab, Itai, Tam, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832161/
https://ncbi.nlm.nih.gov/pubmed/31623098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24203719
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