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CB(1) cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function
INTRODUCTION: CB(1) cannabinoid receptors (CB(1)Rs) stimulate Gi/o-dependent signaling pathways. CB(1)R-mediated cAMP increases were proposed to result from Gs activation, but CB(1)R-stimulated GTPγS binding to Gs has not heretofore been investigated. METHODS: Three models of CB(1)R- stimulated cAMP...
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| Опубликовано в: : | J Basic Clin Physiol Pharmacol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5497837/ https://ncbi.nlm.nih.gov/pubmed/27089415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/jbcpp-2015-0096 |
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