Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

Chronic kidney disease (CKD) differentially affects the pharmacokinetics (PK) of nonrenally cleared drugs via certain pathways (e.g., cytochrome P450 (CYP)2D6); however, the effect on CYP2C8‐mediated clearance is not well understood because of overlapping substrate specificity with hepatic organic a...

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發表在:Clin Pharmacol Ther
Main Authors: Tan, Ming‐Liang, Zhao, Ping, Zhang, Lei, Ho, Yunn‐Fang, Varma, Manthena V.S., Neuhoff, Sibylle, Nolin, Thomas D., Galetin, Aleksandra, Huang, Shiew‐Mei
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246729/
https://ncbi.nlm.nih.gov/pubmed/30074626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1205
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