Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

Chronic kidney disease (CKD) differentially affects the pharmacokinetics (PK) of nonrenally cleared drugs via certain pathways (e.g., cytochrome P450 (CYP)2D6); however, the effect on CYP2C8‐mediated clearance is not well understood because of overlapping substrate specificity with hepatic organic a...

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Publicado en:Clin Pharmacol Ther
Autores principales: Tan, Ming‐Liang, Zhao, Ping, Zhang, Lei, Ho, Yunn‐Fang, Varma, Manthena V.S., Neuhoff, Sibylle, Nolin, Thomas D., Galetin, Aleksandra, Huang, Shiew‐Mei
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246729/
https://ncbi.nlm.nih.gov/pubmed/30074626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1205
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