Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP

Our recent studies have shown that chronic kidney disease (CKD) affects the pharmacokinetics (PKs) of cytochrome P450 (CYP)2D6‐metabolized drugs, whereas effects were less evident on CYP3A4/5. Therefore, the effect of CKD on the disposition of CYP1A2‐metabolized, CYP2C8‐metabolized, CYP2C9‐metaboliz...

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Publicado en:Clin Pharmacol Ther
Autores principales: Tan, Ming‐Liang, Yoshida, Kenta, Zhao, Ping, Zhang, Lei, Nolin, Thomas D., Piquette‐Miller, Micheline, Galetin, Aleksandra, Huang, Shiew‐Mei
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947523/
https://ncbi.nlm.nih.gov/pubmed/28990182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.807
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