Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using R-value and physiologically based pharmacokinetic models

Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important determinants of transporter-mediated drug-drug interactions (DDIs). Current studies assessed the OATP1B1 and OATP1B3-mediated DDI potential of vemurafenib, a kinase inhibitor drug with high protein binding and low aqueous s...

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Published in:J Pharm Sci
Main Authors: Kayesh, Ruhul, Farasyn, Taleah, Crowe, Alexandra, Liu, Qiang, Pahwa, Sonia, Alam, Khondoker, Neuhoff, Sibylle, Hatley, Oliver, Ding, Kai, Yue, Wei
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750294/
https://ncbi.nlm.nih.gov/pubmed/32590030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2020.06.016
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