Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner.

OATP1B1 and OATP1B3 mediate hepatic uptake of many drugs (e.g., statins) and can mediate transporter-mediated drug-drug-interactions (DDIs). Bortezomib is the first-in-class proteasome inhibitor drug approved by the U. S. Food and Drug Administration for the treatment of multiple myeloma. The potent...

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Hauptverfasser: Khondoker Alam, Taleah Farasyn, Alexandra Crowe, Kai Ding, Wei Yue
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2017-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC5673231?pdf=render
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