Pre-incubation with everolimus and sirolimus reduces organic anion transporting polypeptide (OATP)1B1- and 1B3-mediated transport independently of mTOR kinase inhibition: implication in assessing OATP1B1- and OATP1B3-mediated drug-drug interactions

Organic anion transporting polypeptides (OATP)1B1 and OATP1B3 mediate hepatic uptake of many drugs including lipid-lowering statins. Current studies determined the OATP1B1/1B3-mediated drug-drug interaction (DDI) potential of mammalian target of rapamycin (mTOR) inhibitors, everolimus and sirolimus,...

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Veröffentlicht in:J Pharm Sci
Hauptverfasser: Farasyn, Taleah, Crowe, Alexandra, Hatley, Oliver, Neuhoff, Sibylle, Alam, Khondoker, Kanyo, Jean, Lam, TuKiet, Ding, Kai, Yue, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759397/
https://ncbi.nlm.nih.gov/pubmed/31047942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.04.019
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