Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans

Seasonal influenza vaccination elicits a diminished adaptive immune response in the elderly, and the mechanisms of immunosenescence are not fully understood. Using Ig-Seq, we found a marked increase with age in the prevalence of cross-reactive (CR) serum antibodies that recognize both the H1N1 (vacc...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Jung, Jiwon, Mundle, Sophia T., Ustyugova, Irina V., Horton, Andrew P., Boutz, Daniel R., Pougatcheva, Svetlana, Prabakaran, Ponraj, McDaniel, Jonathan R., King, Gregory R., Park, Daechan, Person, Maria D., Ye, Congxi, Tan, Bing, Tanno, Yuri, Kim, Jin Eyun, Curtis, Nicholas C., DiNapoli, Joshua, Delagrave, Simon, Ross, Ted M., Ippolito, Gregory C., Kleanthous, Harry, Lee, Jiwon, Georgiou, George
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245176/
https://ncbi.nlm.nih.gov/pubmed/34196304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI148763
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