Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth

The discovery of potent and broadly protective influenza virus epitopes could lead to improved vaccines that are resistant to antigenic drift. Here, we describe human antibody C585, isolated from a vaccinee with remarkable serological breadth as measured by hemagglutinin inhibition (HAI). C585 binds...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Virol
المؤلفون الرئيسيون: Qiu, Yu, Stegalkina, Svetlana, Zhang, Jianxin, Boudanova, Ekaterina, Park, Anna, Zhou, Yanfeng, Prabakaran, Ponraj, Pougatcheva, Svetlana, Ustyugova, Irina V., Vogel, Thorsten U., Mundle, Sophia T., Oomen, Ray, Delagrave, Simon, Ross, Ted M., Kleanthous, Harry, Qiu, Huawei
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2020
الموضوعات:
Structure and Assembly
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158729/
https://ncbi.nlm.nih.gov/pubmed/31826999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01035-19
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