Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth

The discovery of potent and broadly protective influenza virus epitopes could lead to improved vaccines that are resistant to antigenic drift. Here, we describe human antibody C585, isolated from a vaccinee with remarkable serological breadth as measured by hemagglutinin inhibition (HAI). C585 binds...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Qiu, Yu, Stegalkina, Svetlana, Zhang, Jianxin, Boudanova, Ekaterina, Park, Anna, Zhou, Yanfeng, Prabakaran, Ponraj, Pougatcheva, Svetlana, Ustyugova, Irina V., Vogel, Thorsten U., Mundle, Sophia T., Oomen, Ray, Delagrave, Simon, Ross, Ted M., Kleanthous, Harry, Qiu, Huawei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158729/
https://ncbi.nlm.nih.gov/pubmed/31826999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01035-19
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