Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans

Seasonal influenza vaccination elicits a diminished adaptive immune response in the elderly, and the mechanisms of immunosenescence are not fully understood. Using Ig-Seq, we found a marked increase with age in the prevalence of cross-reactive (CR) serum antibodies that recognize both the H1N1 (vacc...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Jung, Jiwon, Mundle, Sophia T., Ustyugova, Irina V., Horton, Andrew P., Boutz, Daniel R., Pougatcheva, Svetlana, Prabakaran, Ponraj, McDaniel, Jonathan R., King, Gregory R., Park, Daechan, Person, Maria D., Ye, Congxi, Tan, Bing, Tanno, Yuri, Kim, Jin Eyun, Curtis, Nicholas C., DiNapoli, Joshua, Delagrave, Simon, Ross, Ted M., Ippolito, Gregory C., Kleanthous, Harry, Lee, Jiwon, Georgiou, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245176/
https://ncbi.nlm.nih.gov/pubmed/34196304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI148763
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