Persistent Antibody Clonotypes Dominate the Serum Response to Influenza Over Multiple Years and Repeated Vaccinations

Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. Given the recent prevalence of influenza H1N1 A/California/7/2009 (CA09), we examined the c...

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Publicat a:Cell Host Microbe
Autors principals: Lee, Jiwon, Paparoditis, Philipp, Horton, Andrew P., Frühwirth, Alexander, McDaniel, Jonathan R., Jung, Jiwon, Boutz, Daniel R., Hussein, Dania A., Tanno, Yuri, Pappas, Leontios, Ippolito, Gregory C., Corti, Davide, Lanzavecchia, Antonio, Georgiou, George
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417944/
https://ncbi.nlm.nih.gov/pubmed/30795981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.01.010
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