Persistent Antibody Clonotypes Dominate the Serum Response to Influenza Over Multiple Years and Repeated Vaccinations

Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. Given the recent prevalence of influenza H1N1 A/California/7/2009 (CA09), we examined the c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Host Microbe
Main Authors: Lee, Jiwon, Paparoditis, Philipp, Horton, Andrew P., Frühwirth, Alexander, McDaniel, Jonathan R., Jung, Jiwon, Boutz, Daniel R., Hussein, Dania A., Tanno, Yuri, Pappas, Leontios, Ippolito, Gregory C., Corti, Davide, Lanzavecchia, Antonio, Georgiou, George
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417944/
https://ncbi.nlm.nih.gov/pubmed/30795981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.01.010
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