Persistent Antibody Clonotypes Dominate the Serum Response to Influenza Over Multiple Years and Repeated Vaccinations

Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. Given the recent prevalence of influenza H1N1 A/California/7/2009 (CA09), we examined the c...

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Gepubliceerd in:Cell Host Microbe
Hoofdauteurs: Lee, Jiwon, Paparoditis, Philipp, Horton, Andrew P., Frühwirth, Alexander, McDaniel, Jonathan R., Jung, Jiwon, Boutz, Daniel R., Hussein, Dania A., Tanno, Yuri, Pappas, Leontios, Ippolito, Gregory C., Corti, Davide, Lanzavecchia, Antonio, Georgiou, George
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417944/
https://ncbi.nlm.nih.gov/pubmed/30795981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.01.010
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