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A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis. Immunization of B10.PL mice with the Ac1–9 peptide, the immunodominant determinant of myelin basic protein (MBP), produced a single episode of EAE followed by recovery and resistance to reinduction of disease....
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1906731/ https://ncbi.nlm.nih.gov/pubmed/17627303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28277 |
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