A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis. Immunization of B10.PL mice with the Ac1–9 peptide, the immunodominant determinant of myelin basic protein (MBP), produced a single episode of EAE followed by recovery and resistance to reinduction of disease....

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Autores principales: Menezes, Juscilene S., van den Elzen, Peter, Thornes, Jordan, Huffman, Donald, Droin, Nathalie M., Maverakis, Emanual, Sercarz, Eli E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906731/
https://ncbi.nlm.nih.gov/pubmed/17627303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28277
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