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Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide

Competitive capture is a process by which different determinants of an unfolding antigen compete for binding to the same MHC class II molecule. The “winning” determinant is then dominantly displayed. For self antigens, T cells with specificity for dominantly displayed determinants will be subject to...

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Detalhes bibliográficos
Main Authors: Maverakis, Emanual, Beech, Jonathan T., Schneider, Susanne, Sercarz, Eli E
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770099/
https://ncbi.nlm.nih.gov/pubmed/18375101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2008.02.004
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