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Alternative Lengthening of Telomeres is a Self-Perpetuating Process in ALT-Associated PML Bodies
Alternative lengthening of telomeres (ALT) is mediated by break-induced replication (BIR), but how BIR is regulated at telomeres is poorly understood. Here, we show that telomeric BIR is a self-perpetuating process. By tethering PML-IV to telomeres, we induced telomere clustering in ALT-associated P...
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| Published in: | Mol Cell |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8245000/ https://ncbi.nlm.nih.gov/pubmed/33453166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.030 |
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