Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes. This requires a continuous de novo synthesis of glutamate, likely involving the action of both pyruvate carboxyla...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Front Neurosci
Κύριοι συγγραφείς: Voss, Caroline M., Arildsen, Lene, Nissen, Jakob D., Waagepetersen, Helle S., Schousboe, Arne, Maechler, Pierre, Ott, Peter, Vilstrup, Hendrik, Walls, Anne B.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Frontiers Media S.A. 2021
Θέματα:
Neuroscience
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244593/
https://ncbi.nlm.nih.gov/pubmed/34220417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.646291
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