Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes. This requires a continuous de novo synthesis of glutamate, likely involving the action of both pyruvate carboxyla...

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Udgivet i:Front Neurosci
Main Authors: Voss, Caroline M., Arildsen, Lene, Nissen, Jakob D., Waagepetersen, Helle S., Schousboe, Arne, Maechler, Pierre, Ott, Peter, Vilstrup, Hendrik, Walls, Anne B.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244593/
https://ncbi.nlm.nih.gov/pubmed/34220417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.646291
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