Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats

Ammonia has a key role in the development of hepatic encephalopathy (HE). In the brain, glutamine synthetase (GS) rapidly converts blood-borne ammonia into glutamine which in high concentrations may cause mitochondrial dysfunction and osmolytic brain edema. In astrocyte-neuron cocultures and brains...

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Main Authors: Fries, Andreas W, Dadsetan, Sherry, Keiding, Susanne, Bak, Lasse K, Schousboe, Arne, Waagepetersen, Helle S, Simonsen, Mette, Ott, Peter, Vilstrup, Hendrik, Sørensen, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948122/
https://ncbi.nlm.nih.gov/pubmed/24346692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.218
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