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Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats
Ammonia has a key role in the development of hepatic encephalopathy (HE). In the brain, glutamine synthetase (GS) rapidly converts blood-borne ammonia into glutamine which in high concentrations may cause mitochondrial dysfunction and osmolytic brain edema. In astrocyte-neuron cocultures and brains...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3948122/ https://ncbi.nlm.nih.gov/pubmed/24346692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.218 |
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