Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte–neuron co-cultures

Hyperammonemia is a major etiological toxic factor in the development of hepatic encephalopathy. Brain ammonia detoxification occurs primarily in astrocytes by glutamine synthetase (GS), and it has been proposed that elevated glutamine levels during hyperammonemia lead to astrocyte swelling and cere...

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Detalhes bibliográficos
Main Authors: Dadsetan, Sherry, Kukolj, Eva, Bak, Lasse K, Sørensen, Michael, Ott, Peter, Vilstrup, Hendrik, Schousboe, Arne, Keiding, Susanne, Waagepetersen, Helle S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734774/
https://ncbi.nlm.nih.gov/pubmed/23673435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.73
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