A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1

A20 is a potent anti-inflammatory protein that mediates both inflammation and ubiquitination in mammals, but the related mechanisms are not clear. In this study, we performed mass spectrometry (MS) screening, gene ontology (GO) analysis, and coimmunoprecipitation (co-IP) in a lipopolysaccharide (LPS...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Meng, Zhaoyou, Xu, Rui, Xie, Lexing, Wu, Yutong, He, Qian, Gao, Pan, He, Xiaohui, Chen, Qiong, Xie, Qi, Zhang, Jiqiang, Yang, Qingwu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233150/
https://ncbi.nlm.nih.gov/pubmed/34023381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100811
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